Ipamorelin
Is a synthetic peptide and selective growth hormone secretagogue that mimics ghrelin to stimulate the pituitary gland. It is known for promoting growth hormone release, supporting body composition goals, and aiding recovery without significantly raising cortisol or prolactin levels.
How It Works
- Binds to the ghrelin receptor (GHS-R1a) in the brain and pituitary gland.
- Triggers a natural, pulsatile release of growth hormone.
- Avoids unwanted spikes in stress hormones like cortisol and prolactin that older peptides caused.
Potential Benefits and Uses
- Studied for increasing lean muscle mass and assisting with fat loss.
- Explored for enhanced recovery from physical training or injuries.
- Sometimes paired with GHRH analogs like CJC-1295 for a sustained hormonal response.
- Initially researched for improving gut motility and treating postoperative ileus.
It is typically administered via subcutaneous injection into fatty tissue, such as the abdomen.
Administration Guidelines:
- Timing: For optimal absorption, it is often recommended to take ipamorelin on an empty stomach, such as immediately before sleep or several hours after the last meal.
- Cycle: It is frequently used in cycles lasting several weeks, sometimes in combination with other peptides like CJC-1295, to support recovery or body composition goals.
Reconstitution and Measurement:
- Preparation: The lyophilized powder is reconstituted with bacteriostatic water for injection.
- Measurement: Precise measurement using an insulin syringe is necessary to ensure accuracy, which depends on the concentration of the mixture. The most common Ipamorelin dosages range from 200 to 300 micrograms (µg) per day,
- Typical Daily Dosing
- Beginner: 100–150 µg once per day (before bed)
- Standard: 200–300 µg per day, split into 2 doses
- Advanced: Up to 400 µg per day (divided into AM/PM injections)
